Clostridium is a genus of Gram-positive, anaerobic bacteria, belonging to theFirmicutes. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans.
From the evolutionary perspective, clostridia are considered to be the most ancient bacteria. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Several species of clostridia (e.g. C. difficile, C. perfringens, C. botulinum, C. tetani) are known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc.), molecular hydrogen and other useful compounds.
Courtesy: Wellcome Image Galary
Clostridium-DTDB is database focussing on the potential drug targets of Clostridium difficile and provides a gateway to the information obtained from sequence annotation of clostridium and human host. This database contains drug target proteins which represents the different stages of development for the organism. Thses drug targets are dertermined by the sequence annotation through comparative genomics and metabolic pathway analysis (i.e. chock point analysis). To retrieve the information, user can search for drug target by protein name or database ID. Finally, user can Browse all the records stored in Clostridium-DTDB. There are currently a total of 21 potential drug target proteins from 3 strain of C. difficile available.